School of Chemistry

Module Aims: Session 2022-2023

MODULE CH3716 : Quantitative Aspects of Medicinal Chemistry

Lecturers:
Dr T. van Mourik*, Professor T. K. Smith and Professor P. A. Wright

(*Module Convenor)

Aims:
The aim of the module is to cover some of the quantitative aspects of Medicinal Chemistry and drug design. Initially some relevant fundamental thermodynamics will be discussed. The thermodynamics of the drug receptor interactions will then be covered along with other aspects of pharmacology. The pharmacokinetic phase of drug action will be described including the absorption, distribution, metabolism and elimination (ADME) of drugs. The use of computational chemistry in the modern drug design process will then be discussed, covering force field calculations, molecular dynamics, molecular docking, QSAR (Quantitative Structure Activity Relationships) and pharmacophores.

  •   Pharmacology and Pharmacokinetics - Professor T. K. Smith

  •   Thermodynamics in Medicinal Chemistry - Professor P. A. Wright

  •   Computational Chemistry for Medicinal Chemists - Dr T. van Mourik